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A recent study by Tohoku University researchers has shed light on the association between dairy product consumption and odd-number carbon chain fatty acids (odd-FA) within the Japanese population, a correlation previously confirmed in Europe and Oceania but understudied in Asian countries.

Details of their research were published in the journal Metabolomics on March 5, 2024.

Odd-FA are fewer in numbers compared to fatty acids with even numbers of carbon atoms. A major source of odd-FA for humans is through dairy, mainly synthesized by microorganisms in the stomachs of ruminants.

"After combing through databases that explored the correlations between food consumption habits and lipids, we honed in on the association between dairy product consumption and odd-FA," says Kengo Kinoshita, co-author of the study, and a professor at Tohoku University's Tohoku Medical Megabank Organization. "While previous studies extensively explored this association in Europe and Oceania, very few have looked into Asian countries."

Kinoshita and his colleagues collected plasma samples and food frequency questionnaires from over 4,000 Miyagi-prefecture residents, to examine daily food consumption and its impact on 439 plasma lipid species.

The study also examined how consuming confectioneries, such as cookies, chocolate, cakes, and wagashi (Japanese-style snacks), reduces omega-3 fatty acids. Competition between omega-3 and omega-6 fatty acids may be the cause, as confectionery and lipids thought to contain omega-6 fatty acids were positively correlated. Given the well-known benefits of omega-3 fatty acids in promoting healthy brain functions, reducing mortality and lowering the risk of cardiovascular diseases, the findings suggest caution should be taken in the confectionary consumption of omega 6 fatty acid.

Addressing the next steps for future studies, the study suggests a key role for odd-FA-containing sphingomyelin (SM) in dietary odd-FA metabolism, offering valuable insights for further research in this area.

"While our findings primarily focus on diet-lipid associations within the Japanese population, we believe that the identification of sphingomyelin (SM) as an important molecule in odd-FA metabolism holds broader significance beyond ethnicity-specific contexts," commented Kinoshita.

The study was part of the ongoing omics research being performed for the Tohoku Medical Megabank Project Community-Based Cohort Study. Commenced in May 2013, this project is conducted by Tohoku University's Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University's Iwate Tohoku Medical Megabank Organization (IMM). Over 80,000 residents are involved.

Since 2011, ToMMo has been deeply involved in monitoring the health of Tohoku residents through cohort studies, collecting genomic data, and creating an integrated biobank. The organization pays particular attention to residents' well-being following the reconstruction of the region after the Great East Japan Earthquake.

Publication Details:

Title: Dietary habits and plasma lipid concentrations in a general Japanese population
Authors: Mitsuharu Sato, Eiji Hishinuma Naomi Matsukawa, Yoshiko Shima, Daisuke Saigusa, Ikuko N. Motoike, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, and Kengo Kinoshita
Journal: Metabolomics
DOI: 10.1007/s11306-024-02087-1

Press release in Japanese